Recent developments in agriculture have stirred up interest in the concept of “sustainable” farming systems. Still it is difficult to determine the extent to which certain agricultural practices can be considered sustainable or not. Aiming at identifying the necessary attributes with respect to sustainability in Dutch dairy farming in the beginning of the third millennium, we first compiled a list of attributes referring to all farming activities with their related side effects with respect to economic, internal social, external social, and (...) ecological sustainability. A wide range of people (i.e., experts and stakeholders) were consulted to contribute to our list of attributes. Our consultation showed that only one attribute was selected for economic and internal social sustainability: profitability and working conditions, respectively. The list for external social sustainability contained 19 attributes and the list for ecological sustainability contained 15 attributes. To assess their relative importance, the same experts and stakeholders ranked the attributes for external social and ecological sustainability by using a questionnaire. The most important attributes for external social sustainability were food safety, animal health, animal welfare, landscape quality, and cattle grazing. For ecological sustainability they were eutrophication, groundwater pollution, dehydration of the soil, acidification, and biodiversity. The present method for identifying and ranking attributes is universal and, therefore, can be used for other agricultural sectors, for other countries, and for other time periods. (shrink)

The second edition of this extensive work is the definitive source on issues pertaining to the full range of topics in the important area of food and agricultural ethics. Altogether about 100 new entries appear in this new edition. The start of the 21st century has seen intensified debate, discussion, and criticism of food and agriculture. Scholars, activists, and citizens increasingly question the goals and ethical rationale behind production, distribution and consumption of food, and the use of crops for fuel (...) and fiber. These wide-ranging debates encompass questions in human nutrition, animal rights, and the environmental impacts of agricultural production. The encyclopedia provides a detailed analysis of these issues and hundreds of other topics including the use of antibiotics in animal feedlots, the Green Revolution, organic farming, Islam and Food, and cannibalism.The Encyclopedia of Food and Agricultural Ethics, 2nd edition is an indispensable reference point for future research and writing on topics in agriculture, food, animal, and eating ethics. (shrink)

The essays in this volume apply philosophical analysis to address three kinds of questions: What are the implications of genetic science for our understanding of nature? What might it influence in our conception of human nature? What challenges does genetic science pose for specific issues of private conduct or public policy?

Thomas Jefferson and Philosophy: Essays on the Philosophical Cast of Jefferson’s Writings is a collection of essays on topics that relate to philosophical aspects of Jefferson’s thinking over the years. Much historical insight is given to ground the various philosophical strands in Jefferson’s thought and writing on topics such as political philosophy, moral philosophy, slavery, republicanism, wall of separation, liberty, educational philosophy, and architecture.

In [P. Larson, Martin’s Maximum and the axiom , Ann. Pure App. Logic 106 135–149], we modified a coding device from [W.H. Woodin, The Axiom of Determinacy, Forcing Axioms, and the Nonstationary Ideal, Walter de Gruyter & Co, Berlin, 1999] and the consistency proof of Martin’s Maximum from [M. Foreman, M. Magidor, S. Shelah, Martin’s Maximum. saturated ideals, and non-regular ultrafilters. Part I, Annal. Math. 127 1–47] to show that from a supercompact limit of supercompact cardinals one could force Martin’s (...) Maximum to hold while the axiom fails. Here we modify that argument to prove a stronger fact, that Martin’s Maximum is consistent with the existence of a wellordering of the reals definable in H without parameters, from the same large cardinal hypothesis. In doing so we give a much simpler proof of the original result. (shrink)

The apolipoprotein E gene plays an important role in the pathogenesis of Alzheimer's disease , and amyloid plaque comprised mostly of the amyloid-beta peptide ) is one of the major hallmarks of AD. However, the relationship between these two important molecules is poorly understood. We examined how A treatment affects APOE expression in cultured cells and tested the role of the transcription factor NF-B in APOE gene regulation. To delineate NF-B's role, we have characterized a 1098 nucleotide segment containing the (...) 5'-flanking region of the human APOE gene . Sequence analysis of this region suggests the presence of two potential NF-B elements. To demonstrate promoter activity, the region was cloned upstream of a promoterless luciferase gene. This segment was able to drive expression of luciferase in transient transfections of human fetal glial cells. Promoter activity was stimulated twofold by A treatment. Pretreatment with double-stranded DNA decoy oligonucleotides against NF-B reduced A stimulation. Deletion and mutagenetic analyses demonstrated that the distal NF-B element was functional and showed a strong DNA-protein complex band in gel shift analysis, similar to that from control NF-B consensus element. An anti-inflammatory and anti-NF-B drug, sodium salicylate, significantly blocked A-induced APOE promoter function. Our data provide evidence that upregulation of APOE by A in astroglial cells is mediated by an NF-B-element present in the 5'-flanking region of the APOE gene. (shrink)

Although I took one class with John McDermott at SUNY Stony Brook, I write as a colleague who came through the ranks under his mentorship at Texas A&M from 1980 to 1997, when I left College Station to assume the Joyce and Edward E. Brewer Chair in Applied Ethics at Purdue University. I came to Texas A&M during the transition from McDermott's term as the Head of the Department of Philosophy and Humanities to the leadership of Professor Hugh McCann. It (...) was a heady time in Central Texas, and especially in philosophy. Texas A&M was itself undergoing rapid growth in both the size of its student population and in the research output of its faculty. The 1980s, in particular, were a time when a faculty member in any... (shrink)

The Spirit of the Soil was updated for its 2nd edition in 2017. Three comments on the update are addressed here. First, productionism was not intended as a explanation of farm management decision m...

In 1967 Paul L'Archevêque published an analytical Index of the works of Teilhard de Chardin which has become an invaluable reference source for the thought of the renowned French scientist. This new Index is to a great extent a continuation and implementation of the former one. While it makes up for some of its deficiencies, it contains many additional references to Teilhard’s works which appeared after 1967, including some unpublished letters and pertinent material from the "Cahiers" of the "Editions (...) du Seuil." A simple look at some of the entries, such as "Christ" with 119 references, "Homme" with 277, "Matière" with 145, and "Vie" with 198, gives an idea of the thoroughness and practical value of this new Index. Thus one can only wholeheartedly agree with Claude Cuénot, the well-known Teilhard scholar and biographer, who, in addition to admitting that both he and the "Fondation Teilhard de Chardin" have greatly profited from the 1967 Index, recommends very highly the Nouvel Index Analytique and expresses the wish that at some future date the two Indexes be combined into one volume with an additional Index of Names. Cuénot’s suggestion has been favorably accepted by the author, who intends to carry out the project as soon as all Teilhard’s works are published.—B. M. B. (shrink)

We present Woodin's proof that if there exists a measurable Woodin cardinal δ, then there is a forcing extension satisfying all $\Sigma _{2}^{2}$ sentences ϕ such that CH + ϕ holds in a forcing extension of V by a partial order in V δ . We also use some of the techniques from this proof to show that if there exists a stationary limit of stationary limits of Woodin cardinals, then in a homogeneous forcing extension there is an elementary embedding (...) j: V → M with critical point $\omega _{1}^{V}$ such that M is countably closed in the forcing extension. (shrink)

In his book on P max [7], Woodin presents a collection of partial orders whose extensions satisfy strong club guessing principles on ω | . In this paper we employ one of the techniques from this book to produce P max variations which separate various club guessing principles. The principle (+) and its variants are weak guessing principles which were first considered by the second author [4] while studying games of length ω | . It was shown in [1] that (...) the Continuum Hypothesis does not imply (+) and that (+) does not imply the existence of a club guessing sequence on ω | . In this paper we give an alternate proof of the second of these results, using Woodin's P max technology, showing that a strengthening of (+) does not imply a weakening of club guessing known as the Interval Hitting Principle. The main technique in this paper, in addition to the standard P m a x machinery, is the use of condensation principles to build suitable iterations. (shrink)

In this paper we discuss the epistemological positions of evolution theories. A sharp distinction is made between the theory that species evolved from common ancestors along specified lines of descent (here called the theory of common descent), and the theories intended as causal explanations of evolution (e.g. Lamarck's and Darwin's theory). The theory of common descent permits a large number of predictions of new results that would be improbable without evolution. For instance, (a) phylogenetic trees have been validated now; (b) (...) the observed order in fossils of new species discovered since Darwin's time could be predicted from the theory of common descent; (c) owing to the theory of common descent, the degrees of similarity and difference in newly discovered properties of more or less related species could be predicted. Such observations can be regarded as attempts to falsify the theory of common descent. We conclude that the theory of common descent is an easily-falsifiable & often-tested & still-not-falsified theory, which is the strongest predicate a theory in an empirical science can obtain. Theories intended as causal explanations of evolution can be falsified essentially, and Lamarck's theory has been falsified actually. Several elements of Darwin's theory have been modified or falsified: new versions of a theory of evolution by natural selection are now the leading scientific theories on evolution. We have argued that the theory of common descent and Darwinism are ordinary, falsifiable scientific theories. (shrink)

Remembering Kolmogorov Content Type Journal Article Pages 1-3 DOI 10.1007/s11016-011-9540-6 Authors Paul M. B. Vitányi, CWI, Science Park 123, 1098 XG Amsterdam, The Netherlands Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796.

High-spin states have been studied in Pr-135(59), populated through the Cd-116(Na-23,4n) reaction at 115 MeV, using the Gammasphere gamma-ray spectrometer. The negative-parity yrast band has been significantly extended to spin similar to 45 (h) over bar and excitation energy 21.5 MeV, showing evidence for several rotational alignments. The positive-parity yrast band of Ce-135(58), populated through the p4n channel of this reaction, was also populated to spin similar to 38 (h) over bar and excitation energy 18 MeV. Cranking calculations indicate that (...) these nuclei are soft with respect to the triaxiality parameter gamma and that several competing nuclear shapes occur at high spin. (shrink)

The AMA's Council on Ethical and Judicial Affairs' position statement on “Disaster Preparedness and Response” is a welcome discussion of an important issue: the extent to which physicians have a responsibility to treat people affected by disasters in which the nature, source, and cause of the harm is unclear and where the risk is largely unknown.

The human fovea is known for its distinctive pit‐like appearance, which results from the displacement of retinal layers superficial to the photoreceptors cells. The photoreceptors are found at high density within the foveal region but not the surrounding retina. Efforts to elucidate the mechanisms responsible for these unique features have ruled out cell death as an explanation for pit formation and changes in cell proliferation as the cause of increased photoreceptor density. These findings have led to speculation that mechanical forces (...) acting within and on the retina during development underly the formation of foveal architecture. Here we review eye morphogenesis and retinal remodeling in human embryonic development. Our meta‐analysis of the literature suggests that fovea formation is a protracted process involving dynamic changes in ocular shape that start early and continue throughout most of human embryonic development. From these observations, we propose a new model for fovea development. (shrink)

BackgroundAlthough the number of reporting guidelines has grown rapidly, few have gone through an updating process. The STARD statement (Standards for Reporting Diagnostic Accuracy), published in 2003 to help improve the transparency and completeness of reporting of diagnostic accuracy studies, was recently updated in a systematic way. Here, we describe the steps taken and a justification for the changes made.ResultsA 4-member Project Team coordinated the updating process; a 14-member Steering Committee was regularly solicited by the Project Team when making critical (...) decisions. First, a review of the literature was performed to identify topics and items potentially relevant to the STARD updating process. After this, the 85 members of the STARD Group were invited to participate in two online surveys to identify items that needed to be modified, removed from, or added to the STARD checklist. Based on the results of the literature review process, 33 items were presented to the STARD Group in the online survey: 25 original items and 8 new items; 73 STARD Group members (86 %) completed the first survey, and 79 STARD Group members (93 %) completed the second survey.Then, an in-person consensus meeting was organized among the members of the Project Team and Steering Committee to develop a consensual draft version of STARD 2015. This version was piloted in three rounds among a total of 32 expert and non-expert users. Piloting mostly led to rewording of items. After this, the update was finalized. The updated STARD 2015 list now consists of 30 items. Compared to the previous version of STARD, three original items were each converted into two new items, four original items were incorporated into other items, and seven new items were added.ConclusionsAfter a systematic updating process, STARD 2015 provides an updated list of 30 essential items for reporting diagnostic accuracy studies. (shrink)

We argue that confusability between items should be distinguished from generalization between items. Shepard's data concern confusability, but the theories proposed by Shepard and by Tenenbaum & Griffiths concern generalization, indicating a gap between theory and data. We consider the empirical and theoretical work involved in bridging this gap. [Shepard; Tenenbaum & Griffiths].

We compare the elementary theories of Shannon information and Kolmogorov complexity, the extent to which they have a common purpose, and wherethey are fundamentally different. We discuss and relate the basicnotions of both theories: Shannon entropy, Kolmogorov complexity, Shannon mutual informationand Kolmogorov (``algorithmic'') mutual information. We explainhow universal coding may be viewed as a middle ground betweenthe two theories. We consider Shannon's rate distortion theory, whichquantifies useful (in a certain sense) information.We use the communication of information as our guiding motif, (...) and we explain howit relates to sequential question-answer sessions. (shrink)